Lisa Pierre was born in 1960 at Brooklyn Jewish Hospital in the Crown Heights neighborhood of Brooklyn. Born to parents who'd come up to New York City from Georgia and North Carolina, Pierre attended Public School 316, P.S. 42, I.S. 320 and Prospect Heights High School. She is dedicated to her church, Washington Temple Church of God in Christ, and has worked to provide day care and pre-school in the neighborhood. She is a community activist, with involvement in the Crow Hill Community Association and Parent Teacher Association. Pierre is mother to an adult son and two grown daughters.