The Technical, Office and Professional (TOP) Union, Local 2110, is an amalgamated union with 30 contracts covering over 3,000 workers in universities, publishing, museums, law firms and other offices. They represent teachers, secretaries, administrators, editors, computer operators, librarians, museum curators, typesetters and graphic artists, among many others. The union claims that they've taken the lead in organizing women and workers in non-profits who never had been organized before. They have won benefits such as childcare, flex-time, job classification, domestic partner benefits and family leave and organize and negotiate for "white collar" workers. Their area of representation includes New England, Washington D.C., New York metropolitan area, and Puerto Rico. Some organizations they work with are:

Addison—Wesley Longman Publishers
Ames & Rollinson
AMSCO School Publications
Barnard College
Bronx Museum of the Arts
Church World Service
Columbia University
DASNY: Dormitory Authority of the State of New York
Feminist Press
GOLES: Good Old Lower East Side
HarperCollins Publishers
HFA: New York State Housing Finance Agency
ICCR: Interfaith Center on Corporate Responsibility
Mercy College
Monthly Review
Museum of Modern Art, New York
National Council of Churches
New Press
NYANA: New York Association for New Americans
New York Civil Liberties Union
New—York Historical Society
Rabinowitz, Boudin, Standard, Krinsky & Lieberman, P.C.
SONYMA: State of New York Mortgage Agency
Stamford Advocate
State Bank of India
TCI: Technical Careers Institute
Teachers College
Union Theological Seminary
Village Voice

District 65 traces its origins to the Wholesale Dry Goods Workers Union and New York's Lower East Side. It was one of many unions formed during the early years of the Great Depression. For a considerable period its membership consisted of primarily Jewish garment workers. The Union has a progressive and politically active history. It stood against McCarthyism during the virulent anti-communist, red scare era and stood against the Vietnam War decades later. In 1992, District 65 merged with Local 2110. Local 2110 acquired the records of former bargaining units, including academic records primarily addressing organizing campaigns at Yale and Boston University. The Historical Societies, Church Organizations, and Misc are primarily former bargaining units of D 65.

Some organizing campaigns include: the Lower East Side Tenement Museum, New York University Graduate Student Organizing Committee, Columbia University Teaching and Research Assistants (GSEU), the Hispanic Society, the Guggenheim, Brooklyn Academy of Music, Film Forum, the Brooklyn Museum, the Whitney Museum, and the American Folk Museum. Local 2110 is actively involved in ongoing struggles to unionize each of these institutions.

Some of the issues UAW 2110 advocates for are healthcare reform, the rights of employees when faced with intimidation by employers for participating in Union activities, and bargaining rights.