This series mostly contains correspondence, the majority of which comes from Simon's time as the Program Coordinator of the Inter-American Institute for Labor Studies of ORIT. Some notable correspondents include Julia Vigre, her nephews Gene and Michael H. Granof, American Federation of Teachers President Charles Cogen, Norman Thomas, the Latin American representative to the AFL Serafino Romualdi, Joseph Glazer, and other friends.

Simon also kept detailed journals from her trips to Latin America, Europe, and Israel, documenting who she met and what she did on a day-to-day basis. On her trips, Simon often met with significant international figures in the labor movement, feminist movement, and Socialist Party, including Paulina Luisi, Emilio Frugoni, Oscar Schnake, Jorge González von Marées, Francisco Villagrán, and Ramón Villeda Morales and representatives from SCIDE (Servicio Cooperativo Interamericano de Educación), SITRATERCO (Sindicato de Trabajadores de La Tela Railroad Company), Sindicato Mexicano de Electricistas, Confederacion Revolucionaria de Obreros y Campesinos, SINAMOS (Sistema Nacional de Apoyo a la Movilización Social), SUTE (Sindicato Unico sw Trabajadores) and other unions. Her journals also reveal her disdain of Communists, especially in regard to Communist involvement in the labor movement.

Photographs mostly depict images from Fanny Simon's trips, the bulk of which are from her 1940 trip to South America. Simon also travelled to Europe in 1927; the photographs mostly feature Switzerland and Italy. There are also photographs taken in Mexico and Guatemala. There are some photographs of the United States, including images of Bar Harbor, Jones Beach, Rainbow Landing, the World's Fair in New York, the Smoky Mountains, Yosemite National Park, and Yellowstone National Park. Other nonprint materials also include postcards from her trips, some correspondence from the trips, and an oversized hand-drawn portrait of Simon.

Other materials in this series include articles written by Simon, clippings, day planners, membership cards, and other materials acquired on her travels.

Series II is made up of pamphlets, fliers, clippings, articles, periodicals, newsletters related to land reform and the socialist and labor movement in Latin America, the majority of which date from the 1940s-1970s.

This series also contains drafts and research for her manuscript, "Luis Emilio Recabarren and the Labor Movement of Chile" written in 1948-1949 under a grant from the Social Science research Council. Simon took most of her notes on index cards, which were most likely used to write her manuscript. Simon also appears to have written a manuscript on the Mexico labor movement.

Simon also worked for ICFTU-ORIT as the Program Coordinator of the Inter-American Institute for Labor Studies. Materials related to her work with ORIT include program planning, conference proceedings, press releases, lesson plans, meeting minutes, recruitment and proceedings for the "First ICFTU World Conference on Education in the Labour Movement", their publications, Interamericana and Noticiario Obrero Interamericana, and training manuals, including her manual, "How to Teach: A Manual for the Labor Educator."

This series contains clippings, pamphlets, articles, and other materials related to Spain under the Franco government, from the 1960s to the 1980s. The majority of the materials focus on the Socialist Party under Franco.

This series mostly contains conference proceedings from International Council of Social Democratic Women, Social Democrats USA, and the Socialist International Congress in the 1970s and 1980s. It includes meeting minutes, speeches, correspondence, handwritten notes, circulars, reports, and memoranda from the Socialist International National Action Committee. The majority of materials Simon saved from conferences often relate to events and activities happening within the Socialist Party in Latin America. Simon was active in promoting female leadership in Socialist Party, and worked to promote that through conferences and the International Women's Year and her involvement in Social Democratic Women and Socialist International Women.

This series is comprised of research and educational materials for Simon's labor educator classes and her work with the Workers Defense League and Coalition of Labor Union Women. Materials in this series include clippings, circulars, and other materials.

The majority of the series also includes materials related to the United Federation of Teachers (UFT), including correspondence and memoranda related to the union's protest against the New York City Board of Education's bilingual testing program in 1975, correspondence from teachers outlining curriculum of the bilingual programs in their schools to the union, and the response of the union to ASPIRA v. the New York Board of Education. Other materials related to UFT include lobbying for a higher budget for schools, reports of discrimination by minority teachers to the Office of Civil Rights in the Department of Health, Education, and Welfare, and the treatment of union members in the Panama Canal Zone after 1979.